This paper begins by describing current housing affordability dynamics across Los Angeles and the Inland Empire. Although rent burden metrics help identify households vulnerable to instability, it is the underlying housing and work conditions that shape residents’ lives and produce this indicator—particularly as people cope by working more and living in more crowded households. By comparing conditions driving the affordability crisis, we show that housing pressures found in the Inland Empire are a continuation or extension of Los Angeles dynamics. In response, we emphasize the need to simultaneously examine interrelated housing, labor, and social conditions and their underlying drivers across Southern California.